CAS № 868540-17-4
Carfilzomib is a second-generation, irreversible, peptide epoxyketone class proteasome inhibitor that targets the chymotrypsin-like β5 subunit of the constitutive 20S proteasome (IC50 = 5.2 nM) and the β5i subunit of the immunoproteasome 20Si (LMP7; IC50 = 14 nM) with minimal cross reactivity to other proteases.1,2 It can induce cell cycle arrest and apoptosis in human cancer cell lines including multiple…Continue
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BGP-15 (66611-37-8) Description:
BGP-15 is a novel poly(ADP-ribose) polymerase inhibitor – protects against nephrotoxicity of cisplatin without compromising its antitumor activity. BGP-15 also inhibits caspase-independent programmed cell death in acetaminophen-induced liver injury. Moreover, the hydroxylamine derivative BGP-15 is a coinducer of HSP72 in vitro, but only in the presence of cotreatment with heat and had no effect…Continue
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BGP-15 (CAS 66611-37-8) - LS-H6785
The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 66611-37-8 is a PARP inhibitor and insulin sensitizer. In perfused heart, it blocks self-ADP-ribosylation of nuclear PARP (Ki = 57 µM) and mono-ADP-ribosylation of GRP78, resulting in decreased levels of reactive oxygen species, lipid peroxidation, and single-strand DNA breaks. BGP-15 acts…Continue
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The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis.1 BGP-15 is a PARP inhibitor and insulin sensitizer. In perfused heart, it blocks self-ADP-ribosylation of nuclear PARP (Ki = 57 µM) and mono-ADP-ribosylation of GRP78, resulting in decreased levels of reactive oxygen species, lipid peroxidation, and single-strand DNA breaks.2,3 BGP-15 acts as a co-inducer of heat…Continue
Added by freemexy on July 4, 2019 at 10:48am — No Comments
Robotic arms and temporary motorisation
Next-generation wheelchairs could incorporate brain-controlled robotic arms and rentable add-on motors in order to help people with disabilities more easily carry out daily tasks or get around a city.China Robotics Manufacturer
Professor Nicolás García-Aracil from the Universidad Miguel Hernández (UMH) in Elche, Spain, has developed an automated wheelchair with an exoskeleton robotic arm to use at…Continue
Added by freemexy on July 4, 2019 at 10:42am — No Comments
Paralyzed Woman Moves Robotic Arm With Her Mind
A 58-year-old woman paralyzed by a stroke was all smiles after sipping her cinnamon latte with the help of a mind-controlled robotic arm.
Cathy Hutchinson is one of two tetraplegic patients able to reach and grasp with a robotic limb linked to tiny sensor in her brain, according to a study published today in the journal Nature. The device, called BrainGate, bypasses the nerve circuits broken by the brainstem stroke and replaces…Continue
Added by freemexy on July 4, 2019 at 10:24am — No Comments
A multifaceted future: The jewelry industry in 2020
The trends that have unfolded in the apparel sector over the last three decades appear to be playing out in the jewelry sector, but at a much faster pace.
The jewelry industry seems poised for a glittering future. Annual global sales of €148 billion are expected to grow at a healthy clip of 5 to 6 percent each year, totaling €250 billion by 2020. Consumer appetite for Cheap Jewelry…
Added by freemexy on July 4, 2019 at 10:19am — No Comments
Here's where you can score sparkling costume jewelry
Whenever Lupita Nyong'o or Meryl Streep dazzle on the red carpet — which is basically every time they step a well-heeled foot on one — much of the credit goes to Micaela Erlanger.
She’s the superstar stylist responsible for some of Hollywood’s most standout looks, and the author of “How to Accessorize: A Perfect Finish to Every Outfit.” Plus, she’s a big fan of something most of us slip on to top off an what could be an…Continue
Added by freemexy on July 4, 2019 at 10:12am — No Comments
The changing face of sex toys: Innovations in the industry prioritise female pleasure
It had been a good couple of decades since I had wandered into an adult store but to my surprise, the passage of time wasn't making it any easier.
Needing to interview an adult store proprietor who was retiring after 25 years in the game, I found myself, technically now a grown man, once again reduced to a bundle of nerves as I waited for a break in pedestrian traffic to allow as inconspicuous…Continue
Added by freemexy on July 4, 2019 at 10:05am — No Comments
Women’s volleyball captain Zhu leads China into Asian Games
A towering volleyball player who makes her living in Turkey is the unrivalled star of China’s squad at the Asian Games in Indonesia.Zhu Ting is something of an anomaly in China’s sporting world, which still largely relies on its highly disciplined and deeply nationalistic sports academies to produce champions who dominate at events such as the Asiad.To get more china women's…Continue
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Chinese Superstar Gong Li Talks Women, Shanghai, Scripts and Tax
Chinese acting superstar Gong Li was last month the recipient of the Kering Women In Motion award at Cannes. She spoke with Variety at the Shanghai International Film Festival about her upcoming roles, the political context of acting today, and her return to Shanghai.To get more shanghai women, you can visit shine news official website.
Added by freemexy on July 4, 2019 at 9:54am — No Comments
‘We put our marriage through the divorce predictor equation and wow’
My phone recently pinged up a notification that a Wall Street Journal article on the mathematics behind lasting love was trending and being a long term in-love-ite, I clicked on it with interest.To get more divorce test, you can visit shine news official website.
My husband and I met at the young age of 18, nearly 25 years ago, and there have been times…
Added by freemexy on July 4, 2019 at 9:40am — No Comments